دکتر بیتا ضمیری

Education:

Doctor of Philosophy – Pharmaceutical Sciences 
Sep. ۲۰۱۱ – June ۲۰۱۶
University of Toronto, Toronto, ON


Bachelor of Applied Science – Chemical Engineering                                                    
Sep. ۲۰۰۶ – Dec. ۲۰۱۰
University of Tehran, Tehran, Iran



 
Publications:

Kalaak Reddy, Bita Zamiri, Sabrina Stanley, Robert B. Macgregor Jr. and Christopher E. Pearson.
The disease associated r(GGGGCC)n from the C۹orf۷۲ gene forms tract length-dependent uni- and multi molecular RNA G-quadruplexes. Journal of Biological Chemistry (JBC) (Impact factor: ۴.۵۷), April ۵, ۲۰۱۳
 Bita Zamiri, Kaalak Reddy, Robert B. Macgregor Jr. and Christopher E. Pearson.
TMPyP۴ distorts RNA G-quadruplex structures of the disease associated r(GGGGCC)n repeat of the C۹orf۷۲ gene and blocks interaction of RNA-binding proteins.  Journal of Biological Chemistry (JBC), (Impact factor: ۴.۵۷), December ۲۶, ۲۰۱۳ (selected as the cover of the JBC journal)
 Bita Zamiri, Mile Mirceta, Karol Bomsztyk, Robert B. Macgregor Jr. and Christopher E. Pearson.
Quadruplex formation by both G-rich and C-rich DNA strands of the C۹orf۷۲ (GGGGCC)۸.(GGCCCC)۸ repeat: Effect of CpG methylation. Nucleic Acids Research (NAR). (Impact factor: ۹.۲) October ۲, ۲۰۱۵. (Featured in ALS Canada Research and selected as the cover of NAR journal)
 Yun Li Yang , Rashid Abu-ghazalah, Bita Zamiri and Robert B. Macgregor Jr.
Concentration-dependent conformational changes in GQ forming ODNs. Biophysical Chemistry. (Impact factor: ۲.۳۶) February ۱۷, ۲۰۱۶.
Taro Ishiguro, Nozomu Sato, Nobuhiro Fujikake, Chantal Sellier, Akemi Kanegami, Morio Ueyama, Takanori Yokota, Keiji Wada, Bita Zamiri, Terrence Gall-Duncan, Mila Mirceta, Christopher E. Pearson, J.Paul Taylor, Nicolas Charlet-Berguerand, Hidehiro Misusawa, Yoshitaka Nagai and Kinya Ishikawa.
Regulatory role of RNA chaperone TDP-۴۳ for RNA misfolding and repeat-associated translation in SCA۳۱. Neuron (Impact factor: ۱۵.۰۵) April, ۵, ۲۰۱۷
Taro Ishiguro, Nozomu Sato, Nobuhiro Fujikake, Chantal Sellier, Akemi Kanegami, Morio Ueyama, Takanori Yokota, Keiji Wada, Bita Zamiri, Terrence Gall-Duncan, Mila Mirceta, Christopher E. Pearson, J.Paul Taylor, Nicolas Charlet-Berguerand, Hidehiro Misusawa, Yoshitaka Nagai and Kinya Ishikawa.
Balance between RNA binding proetin TDP-۴۳ and an RNA UGGAA repeat underlies pathogenesis of spinocerebellar ataxia type ۳۱ (SCA۳۱) and motor neuron disease fly models. Jounral of Neurological Sciences (Impact Factor: ۲.۴۷۴) October ۱۵, ۲۰۱۷
Hasan Y. Al-Niss, Bita Zamiri, Melissa Khalaj, Chritopher E. Pearson and Robert B. Macgregor Jr.  
Thermodynamic and spectroscopic investigations of TMPyP۴ association with guanine- and cytosine- rich DNA and RNA repeats of C۹orf۷۲. Biochem Biophys Res Commun. (Impact factor: ۲.۲۹) Jan ۲۲, ۲۰۱۸
Bita Zamiri, Mila Mirceta, Rashid Abu-ghazalah, Mark Wold, Christopher E. Pearson and Robert B. Macgregor Jr.
Stress-induced acidification may contribute to formation of unusual structures in C۹orf۷۲ repeats. Biochim Biophys Acta. (Impact Factor: ۴.۷) March ۱۵, ۲۰۱۸
Javad Mokhtari, Maryam Nourisefat, Leila Fotouhi, Bita Zamiri, Amir-Hassan Zarnani, Aliakbar Moosavi-Movahedi and Khashayar Karimian
Mate and Separate: Isolation and Purification of biological molecules in homogeneous systems by phase transition of their PEGylated recognition counterparts, Under Review, April ۲۰۱۹
Mate and Separate Technique, National Patent Pending, March ۲۰۱۹
Javad Mokhtari, Maryam Nourisefat, Leila Fotouhi, Bita Zamiri, Amir-Hassan Zarnani, Aliakbar Moosavi-Movahedi and Khashayar Karimian