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| Last update: 2026/10/14 |
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Research in regenerative medicine has shown that engineered substrates that simultaneously mimic the distinctive surface topography of bone-forming cells and the piezoelectric properties of bone tissue (the ability to generate an electric charge in response to mechanical force) can guide stem cells toward bone tissue formation without the use of chemical agents.According to AUT’s Public Relations Office, the research project was conducted by Fatemeh Pouladzadeh, a PhD graduate of Amirkabir University of Technology (AUT), under the supervision of the late Dr. AliAsghar Katbab and Dr. Shadab Bagheri-Khoulenjani, faculty members at AUT, in collaboration with Dr. Shahin Bonakdar, a faculty member at the Pasteur Institute of Iran. The results showed that stem cells cultured on these substrates exhibited favorable growth and viability, with initial signs of bone formation observed after just seven days.According to Pouladzadeh, part of the research findings has been published in the Journal of Materials Chemistry B, while the second part of the study is being prepared for publication. Key advantages of this technology include the reusability of the substrates and their potential to reduce costs and improve the safety of therapeutic cell production.The technology may have future applications in areas such as bone tissue engineering, cell therapy, the treatment of complex fractures and bone defects, and the development of bioactive implants. The next step in the research will involve in vivo studies and animal testing to assess the system’s ability to regenerate bone tissue in the living body.
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