Biointerface

 | Post date: 2020/06/10 | 



Supervisor: Dr. Akbar Karkhaneh, Dr, Hamid Keshvari
Phone:
Email: keshvariaut.ac.ir,  a.karkhanehaut.ac.ir
Address:

Introduction:
The interplay between biomaterials and biological system components (including biomolecules, cells, and tissues) plays an important role in the biocompatibility and function of these substances in the body. In this lab, using science and engineering, the focus is on designing and manufacturing biomaterials with functional and environmentally friendly features. Among the most important areas of activity in this laboratory are the design and development of scaffolds and biomaterials with interactive surfaces and / or gradient interfaces and surface modifications and masses of such materials (including oxygenated biomaterials, electrically conductive scaffolds, and composite systems). Hydrogel / fiber and hydrogel / particle), appropriate controlled release carriers (growth factor, DNA and RNA, as well as drugs for the treatment of diseases including cancer), and design of new biomaterials as implants and tissue replacements including replacements. The skin is for wound healing and vascular replacements with no clotting capability.

Gradient scaffolds for tissue engineering interface:
The interface of bone and cartilage that is composed of two different tissues. The two textures are quite different in chemical structure, mechanical properties, electrical properties and oxygen and nutrient requirements. Therefore, the design needed to make scaffold for this interface must have gradient-shifting properties. In this research team, many studies have been carried out on the design and fabrication of gradient scaffolds and the necessary modifications to make it suitable for the interface of bone and cartilage segment.





Oxygen Biomaterials in Tissue Engineering:
One of the major challenges in tissue engineering is delivering oxygen and nutrients to cells in the 3D structure of the scaffold upon entry into the body. Homogeneous and adequate oxygen distribution facilitates cell migration, ECM production, angiogenesis and tissue growth, and prevents cell death and tissue necrosis. For tissue engineering of various organs, in the laboratory, food and oxygen are supplied through the bioreactor, but after implantation in vivo we are faced with oxygen and nutrient limitations. In this research team, several projects have been or are currently being implemented to address this problem using oxygenated biomaterials within tissue engineering scaffolds.
 
Development of Drug Delivery Carriers and Therapeutic Agents in Cancer Diseases:
  To minimize the side effects of conventional cancer treatment (surgery, radiotherapy and chemotherapy) on healthy tissues and to target drug transfer and therapeutic agents to cancer cell sites and improve therapeutic efficacy, today widely used nanomaterials as the carrier used to treat cancer. Features such as increased bio-efficacy and reduced toxicity caused by chemotherapy drugs have led world-renowned research centers in the field to conduct much of their research on various types of carriers (liposomes, polymeric nanoparticles, polymers). Dendrites and nanomaterials). In line with this growing global trend, our research team also focuses on this area. The development of nanoparticles and micelles capable of releasing anticancer drugs is an example of ongoing research.
 


 

 

 
If you are interested in collaborating with this research laboratory, you can contact Dr. Akbar Karkhaneh (a.karkhanehaut.ac.ir) and Dr. Hamid Keshvari (keshvariaut.ac.ir).

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