(Department) Biomedical Engineering (Division) Biomaterials and Tissue Engineering
(Level and Major) Undergraduate
Course Title Synthesis and Fabrication Methods of Tissue Engineering Scaffolds
Number of Credits 3 Prerequisite Engineering Materials 2: Forming and Fabrication
Aims:
In this course, students become familiar with the importance of scaffold in tissue engineering, utilized materials, characterization and fabrication methods
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Syllabus:
1- Section 1:
1-1- Introduction
1-2- Importance of scaffold in tissue engineering
1-3- Interaction of scaffold and biological environment
1-4- Characteristics of functional scaffolds in tissue engineering (chemical, mechanical, structural and architectural, biological and degradability)
2- Section 2:
2-1- Importance of material selection in tissue engineering scaffolds
2-2- Biological, ceramic, metallic, polymeric and composite materials (general introduction of each, processability, degradability and mechanism of degradation and disposal of degradation products)
3- Section 3:
3-1- Fabrication processes of scaffolds:
Melt molding, Gas foaming, Solvent casting, Particulate leaching, Phase separation, Freeze drying, Textile technology, Particle-aggregation, Gel formation, Polymerization, Rapid prototyping, Extrusion, Lithography
4- Section 4: Bioreactors
4-1- Definition, importance in tissue engineering, the basis and factors affecting performance
4-2- Types of bioreactors:
Spinner Flask, Rotating Wall, Flow Perfusion, Compression, Strain, Hydrostatic Pressure, Hollow Fiber, Fluidized-bed, Bubble Column / Air-lift, Bag
References:
1- Methods of Tissue Engineering, Antony Atala, Rebert Lanza, Academic Press, 2002.
2- Functional 3D Tissue Engineering Scaffolds: Materials, Technologies, and Applications, Woodhead Publishing, Ying Deng & Jordan Kuiper, 2017.
3- Scaffolding In Tissue Engineering, Peter X. Ma, Jennifer Elisseeff, CRC Press, 2005, Materials, Second Edition, Andreas F von Recum, 1986.