(Department)  Biomedical Engineering         (Division)      Biomaterials and Tissue Engineering
 
 (Level and Major)   MSc; Elective Course         
 

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Course Title                Biocompatibility                      
 
Number of Credits       3             Prerequisite Cellular and Molecular Biology

Course Description:
Biocompatibility is a general term and refers to the compatibility of a substance with living tissue. There are various biocompatibility tests, some of which are mandatory on products based on international standards such as ISO and FDA. In this course, the student will be introduced to the concepts of biocompatibility, blood compatibility, and biocompatibility testing methods. For example, if the substance would cause a reaction with living tissue, such as immunological reactions (sensitization, irritation, etc.) or toxic reactions.
 
Course Goals and Objectives:
The purpose of this course is to acquaint students with the concepts of biocompatibility, physical and chemical properties of biomaterials and the interactions of biomaterials with cells. Types of tests to evaluate the biocompatibility of a material for biomedical engineering applications are also described.
 
Course Topics:
1. Definitions of biocompatibility and biomaterials
2. Biocompatibility from the point of view of toxicology, desensitization, effect on genes and blood, carcinogenicity and biodegradability.
3. Introduction of biocompatibility standards ANSI, FDA, ISO, FDA
4. Interaction of cells with biomaterials
5. Physical and chemical properties of biomaterials and their biocompatibility
6. Identification of hard and soft tissues and their viscoelastic properties (mechanical properties of bone) and introduction of Maxwell and Voight models
7. Blood compatibility and factors affecting it
8. Methods for detecting blood compatibility levels
9. Wound healing process in the presence of biomaterials
10. Natural and artificial vessels and mechanics of artificial vessels
11. Methods of manufacturing blood compatible biomaterials
12. Ex vivo, in vivo, in vitro biocompatibility test systems
       1) Methods of testing the biocompatibility of the material using methods such as the method of tissue culture medium agar overlay method (tissue culture), culture medium suspension (Culture Suspension), Animal Implantation. As well as methods for examining histological results.
       2) In the Implantation method, each of the following steps should be done practically. Implantation, Fixation, Dehydration, Embedding, Sectioning, Staining and microscopy.
       3) Immunology and blood coagulation systems, main tissues and techniques for identifying cells and tissues, tissue and blood reactions with biomasses and their evaluation, microbial structure and properties of implants in the body, carcinogenicity and biomaterials
 
The course aims to:
Upon successful completion of this course, students will be able to meet these objectives:

• Describe the biocompatibility of biomaterials and its standards.
• Explain blood compatibility, its importance and the construction of blood compatible biomaterials.
• Have learned biocompatibility tests for practical applications.

 
Reading Resources:
1- Biomaterials (Journal),
2- Journal of Biomedical Materials Research, 1980.
3- Biomaterials, an Introduction, J. B. Park, Plenum Press, 1992.
4- Biomaterials Science, Buddy D. Ratner, Academic Press, 1996.
5- Cardiovascular Biomaterials, G.W.HASTINGS, Springer-Verlag, 1992.
6- Polymers: Their Properties and Blood Compatibility, S. Dawids.
 
 
Evaluation (100 total score):
Class attendance and class activity
Project
Midterm exam
Final exam