Nanobiotechnology in Tissue Engineering

(Department)  Biomedical Engineering         (Division)      Biomaterials and Tissue Engineering
 
 (Level and Major)   Graduate course, Tissue Engineering         
 

Course Title                Nanobiotechnology in Tissue Engineering                              
 
Number of Credits       3             Prerequisite -


Course Description:
The objective of the course is to familiarize the students with fundamental principles of nanotechnology and the basic concepts of applying such interdisciplinary principles to develop new biomaterial for tissue engineering and regenerative medicine applications.
 
Course Goals and Objectives
At the end, the students are expected to learn the basics of nanotechnology, unique properties of materials at nanoscale and their interactions with the cells. The students are also expected to get familiar with the fabrication methods for different nanostructures and be able to use learned concepts for better control of cell behavior and enhanced performance of tissue engineering products.
 
Course Topics        
 
  1. An introduction to nanotechnology and nanostructures
  2. Importance of nanostructures in medicine, tissue engineering and cancer therapy
  3. The nanoworld: the fundamental importance of size
  4. Fabrication of nanostructures
  5. Techniques for analysis of nanostructures (a brief review)
  6. Self-assembly
  7. Cell behavior toward nanostructured surfaces  (surface modification at nanoscale)
  8. Control of cell behavior with nanostructures (stem cell engineering)
  9. Examples of the use of nanotechnology in tissue engineering
  10. Nanotechnology and drug and gene delivery
  11. Nanotechnology and diagnosis (nanobiosensors)
  12. Nanostructures for cancer diagnostics and therapy
  13. Nanomedicine in theranostics (nanotheranostics)
  14. Ethical and safety issues
 
 Reading Resources
1.  Binns, C. Introduction to Nanoscience and Nanotechnology. (Wiley, 2010).
2.  Thomas, S., Grohens, Y. & Ninan, N. Nanotechnology Applications for Tissue Engineering. (Elsevier Science, 2015).
3.  Laurencin, C. T. & Nair, L. S. Nanotechnology and Regenerative Engineering: The Scaffold, Second Edition. (Taylor & Francis, 2014).
4.  Tibbals, H. F. Medical Nanotechnology and Nanomedicine. (CRC Press, 2017).
5.  Gonsalves, K., Halberstadt, C., Laurencin, C. T. & Nair, L. Biomedical Nanostructures. (Wiley, 2007).
6.  Goodsell, D. S. Bionanotechnology: Lessons from Nature. (Wiley, 2004).
7.  Lee, Y. S. Self-Assembly and Nanotechnology: A Force Balance Approach. (Wiley, 2008).
8. Nouailhat, A. An introduction to Nanoscience and Nanotechnology. (John Wiley & Sons, Inc, 2010).
9. Roduner, E. Nanoscopic Materials Size- dependent Phenomena. (2002).
10. Israelachvili, J.N. Intermolecular and surface forces. (Academic Press, London, 1992).
11. Ramakrishna, S. An Introduction to Electrospinning and Nanofiber. (World Scientific Publishing, Company, 2004).
12. Ramalingam, M., Vallittu, P., Ripamonti, U. Tissue Engineering and Regenerative Medicine: A Nano Approach. (CRC Press, 2012).
13. Review articles
 
 Evaluation
Midterm exam, Final exam, Paper presentation

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