Fabrication of Biomaterials Usable in Cardiovascular Implants

Dr. Helma Vakili, an Amirkabir University graduate and the executor of "examination of the simultaneous impact of the two hydrophobic and hydrophilic components on polyurethane hybrid coatings’ blood compatibility" project, stated: "This research has succeeded in generating blood-compatible biomaterials that are usable in cardiovascular implants such as cardiac stents, heart valves, and other biomaterials in contact with the arteries and heart by working on polymer coatings’ surface chemistry”
Results of this research indicated that a combination of anticoagulation strategies in a material and the simultaneous presence of hydrophobic and hydrophilic components will result in the formation of a more clot-resistant and blood-compatible surface compared to when these two components are used separately, which could save thousands of lives.
It is also worth mentioning that this project has been conducted as a doctoral dissertation under the supervision of Dr. Mohsen Mohseni, faculty member of AUT’s Polymer Engineering department, and Dr. Hossein. Qanbari, faculty member of innovative medical technologies, University of Tehran. The advising professors of the dissertation were also Dr. Hessam Macci and Dr. Hossein Yahyaii, faculty members of AUT’s Polymer Engineering department. Also, parts of Dr. Vakili’s research has been carried out during a sabbatical in Spain.
It must be mentioned that the innovations of this research include the generation of a super-hydrophilic system with minimal water absorption, the study of polyethylene glycol and POSS components’ simultaneous impact on blood-compatibility, fabrication of polycarbonate-based polyurethane nanocomposites containing polyethylene glycol and POSS, employing a new technique for polyurethane synthesis simulation, and examination of the microstructure and water interactions in hydrophilic polyurethane systems using molecular dynamics simulation tools, all of which were conducted for the first time in the world.



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