AKBAR KARKHANEH - Amirkabir University of Technology

Supervised PhD Theses

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Thesis title

By

Date

1

Studying the effect of nanolayer of hydroxyapatite coating on cell-imprinted substrates on targeted osteogenic differentiation of mesenchymal cells

MORTEZA MEHRJOO
Other Supervisor: MASOUMEH HAGHBIN NAZARPAK

2025 Oct

Supervised MSc Theses

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Thesis title

By

Date

1

Design and preparation of a microparticle-hydrogel hybrid wound dressing with hydrogen sulfide-releasing ability

SABA SAYYAREH

2024 Aug

2

Printing and optimization of antibacterial wound dressing based on chitosan hydrogel with drug release ability

ZAHRA KOOZEGAR & MASOUMEH HAGHBIN NAZARPAK
Other Supervisor:

2024 Aug

3

Fabrication of piezoelectric three-dimension scaffold with oxygen release capability for use in bone tissue engineering applications

NAZANIN JAFARIPOUR

2024 Feb

4

Fabrication and characterization of a dual-drug loaded silk fibroin hydrogel for chemotherapy of glioblastoma and reconstruction of the cavity created after surgical resection

NADIA SHAFAEI & Mohammad Moeini
Other Supervisor:

2024 Feb

5

Experimental investigation of Nitric Oxide release from polysaccharide based wound dressings

MAHBOUBEH SHAFIEI

2024 Feb

6

Fabrication and characterization of alginate-based hydrogel wound dressing reinforced by lignin with drug release capability

FAEZE SHOJAEINIA & MASOUMEH HAGHBIN NAZARPAK
Other Supervisor:

2023 Jul

7

Investigating the effect of aloe vera on the release of dexamethasone from polyvinyl alcohol-based nanofibrous wound dressings

ARMIN BARGHI & MASOUMEH HAGHBIN NAZARPAK
Other Supervisor:

2023 Feb

8

Optimization of the concurrent release of oxygen and dexamethasone by altering the microstructure of the polyester-based carrier

SOGOL YOUNESI

2023 Feb

9

Experimental investigation of osteogenic differentiation of mesenchymal stem cells, in an injectable scaffold with the capability of releasing oxygen and magnesium ions

MINA MALEKI

2022 Jun

10

Design and fabrication of oxygen releasing system to reduce hypoxia induced drug resistance in cancer

NEGAR AKBARI

2022 Jun

11

Fabrication of self-assembled nanocarriers, based on hydrophobically modified polysaccharides, for anti-cancer drug

FATEMEH SHABANI

2022 May

12

Preparation of Micelle based on Amphiphilic Polysaccharide for Anti-cancer Drug Release

NAYEREH AZIMIJOU

2021 Oct

13

Experimental investigation of magnesium ion release from photocrosslinkable hydrogel, functionalized with thiol groups, in bone tissue engineering

SEYYED AHMAD SEYYED NASROLLAH

2021 Oct

14

fabrication and characterization of poly pyrrole-based conductive hydrogel for tissue engineering application

VAHID HEIDARI
Other Supervisor: Iman Shabani

2020 Sep

15

Investigation of cell imprinting effect on inflammation reduction in chondrosarcoma

ZAHRA BOZORGMEHR

2020 Feb

16

Fabrication and characterization of microparticles with oxygen-releasing material as bone tissue scaffold

ELHAM MOHSENI VADEGHANI

2020 Feb

17

Design and synthesis of particles with controlled release of oxygen

SARA NEJATI

2020 Jan

18

Preparation and investigation of conductive hydrogel scaffolds reinforced with fibers coupled collagen for neural tissue engineering

ALIREZA MAHJOUBNIA
Other Supervisor: MASOUMEH HAGHBIN NAZARPAK

2019 Sep

19

An Investigation into curcumin release from PLA particles loaded in PCL-GELATIN fibers for skin application

MISAGH SAADIPOUR
Other Supervisor: MASOUMEH HAGHBIN NAZARPAK

2019 Jul

20

Preparation and evaluation of electrospun nanofibrous scaffolds based on gelatin and polypyrrole for nerve tissue engineering applications

FATEMEH IMANI
Other Supervisor: Iman Shabani

2019 Feb

21

Fabrication and characterization of silk/pectin hydrogel scaffold containing PLLA nanofibers

FERESHTEH AHADI

2018 Oct

22

fabrication of silk- halloysite nanocompisites modified with vancomycin as bone tissue engineering scaffold

FARZANEH AAVANI

2018 Jan

23

Fabrication and evaluation of nano-composite electrospun scaffold based on PCL, PVDF , HA with piezoelectric properties for bone tissue engineering

NARGES AKBARI

2017 Oct

24

the study of chondrocyte behaviors on the drug loaded scaffold under hydrostatic pressure

SANA ANSARI

2017 Oct

25

The effect of Copper ion release from silk fibroin nanocomposite scaffolds on the behavior of Endothelial cells

ZAHRA AFZALI

2017 Jul

26

Manufacturing and characterization of nanofibrous composite scaffold based on polypyrrole grafted cellulose acetate for neural tissue engineering application

FARNOOSH SAEEDINEJAD
Other Supervisor: Iman Shabani

2016 Oct

27

Manufacturing of nanofibrous scaffold containing stimulating drug for mesenchymal stem cell differentiation based on chitosan for cartilage tissue engineering

NEGINSADAT YARANDI

2016 Aug

28

Design and manufacturing of injectable conductive scaffold for cardiac tissue engineering

FARINAZ KETABAT

2016 Feb

29

Design and preparation of alginate nanocarriers for oral drug delivery

SALIME BAZBAN SHOTORBANI

2016 Feb

30

design and manufacture of alginate-gelatine-poly(3,4-ethlenedioxythiphene) poly (styrenesulfonate) scaffold to study the effect of electrical conducctivity on cell for ophthalnic application

MASOUMEH HESAM MAHMOUDINEZHAD

2016 Feb

31

Preparation and characterization of fiber-hydrogel composite as a cartilage tissue engineering scaffold

FATEMEH MOHABATPOUR

2015 Oct

32

Synthesis of a delivery system based on polyurethane and evaluation of sustained release of astatine products

BEHNAZ SADAT EFTEKHARI

2015 Sep

33

Fabrication and characterization of polysaccharide/polypyrrole wound dressing with photothermal and antioxidant properties

MOBINA SARIKHANI

2025 Oct

Books

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Title

Author(s)

Publisher country

publication date

version

1

Electrical and Physical Stimulation in Tissue Engineering ( A chapter of Handbook of Oral and Maxillofacial Surgery and Implantology)

A. Karkhaneh, S. Arabyazdi, S. Younesi, S. Khorshidi Esfandabadi

Switzerland

1

2

engineering of stealth nanocarriers in drug delivery

A. Karkhaneh, N. Shafaei, N. Azimijou

Iran

1

Journal Papers

1

M. Mehrjoo, A. Karkhaneh, M. Haghbin Nazarpak, Mostafa Alishahi, Shahin Bonakdar, "Hydroxyapatite-induced bioactive and cell-imprinted polydimethylsiloxane surface to accelerate osteoblast proliferation and differentiation: an in vitro study on preparation and differentiating capacity", Biomedical Materials, 2025 Jul vol. 20, no. 4, pp.1-16, 2025.

2

F. Shojaeinia, M. Haghbin Nazarpak, A. Karkhaneh, "Antioxidant and antibacterial alginate/lignin composite hydrogels loaded with vancomycin for wound dressing applications", Journal of Biomaterials Applications, 2025 Jun vol. , no. , pp.-, 2025.

3

M. Maleki, R. Karimi Soflou, A. Karkhaneh, "Development of an in situ forming hydrogel concurrently delivering oxygen and magnesium for bone tissue engineering", Applied Materials Today, 2025 Apr vol. 44, no. 1, pp.1-16, 2025.

4

N. Azimijou, R. Karimi Soflou, A. Karkhaneh, "CD44 targeted-chondroitin sulfate nanoparticles: Fine-tuning hydrophobic groups to enhance in vitro pH-responsiveness and in vivo efficacy for advanced breast cancer treatment", Biomaterials Advances, 2024 Apr vol. 158, no. 1, pp.1-15, 2024.

5

F. Shabani, R. Karimi Soflou, A. Karkhaneh, "Folate-mediated targeting of carrageenan-cholesterol micelles for enhanced breast cancer treatment", European Polymer Journal, 2024 Mar vol. 208, no. 112852, pp.1-12, 2024.

6

M. Maleki, A. Karkhaneh, R. Karimi Soflou, "Raspberry-like PLA/PGS biodegradable microparticles with urethane linkages: Unlocking tailored release of magnesium ions and oxygen for bone tissue engineering", International Journal of Pharmaceutics, 2023 Dec vol. 651, no. 1, pp.1-15, 2023.

7

N. Azimijou, R. Karimi Soflou, A. Karkhaneh, "Actively targeted delivery of tamoxifen through stimuli-responsive polymeric nanoparticles for cancer chemotherapy", Journal of Drug Delivery Science and Technology, 2023 Jul vol. 87, no. 1, pp.1-14, 2023.

8

N. Shafaei, S. Khorshidi Esfandabadi, A. Karkhaneh, "The immune-stealth polymeric coating on drug delivery nanocarriers: In vitro engineering and in vivo fate", Journal of Biomaterials Applications, 2023 Jul vol. 0, no. 0, pp.1-20, 2023.

9

S.A. Seyyed Nasrollah, R. Karimi Soflou, A. Karkhaneh, "Photo-click crosslinked hydrogel containing MgO2-loaded PLGA microsphere with concurrent magnesium and oxygen release for bone tissue engineering", Materials Today Chemistry, 2023 Feb vol. 28, no. 1, pp.1-16, 2023.

10

M. Shabani Samghabadi, A. Karkhaneh, A. Katbab, "Synthesis and characterization of biphasic layered structure composite with simultaneous electroconductive and piezoelectric behavior as a scaffold for bone tissue engineering", Polymers For Advanced Technologies, 2023 Jan vol. 0, no. 0, pp.1-14, 2023.

11

R. Karimi Soflou, A. Karkhaneh, "Redox-Sensitive multifunctional hyaluronic acid-based nanomicelles with Fine-controlled anticancer drug release", International Journal of Pharmaceutics, 2022 Nov vol. 629, no. 1, pp.1-12, 2022.

12

S. Khorshidi Esfandabadi, A. Karkhaneh, "Cylindrical polyester/calcium peroxide oxygen-releasing microparticles: molecular dynamics simulation and experimental analyses", Iranian Polymer Journal, 2022 Oct vol. 32, no. 1, pp.45-58, 2022.

13

R. Karimi Soflou, A. Karkhaneh, I. Shabani, "Size-adjustable self-assembled nanoparticles through microfluidic platform promotes neuronal differentiation of mouse embryonic stem cells", Biomaterials Advances, 2022 Jul vol. 140, no. 1, pp.1-13, 2022.

14

N. Akbari, S. Khorshidi Esfandabadi, A. Karkhaneh, "Effect of piezoelectricity of nanocomposite electrospun scaffold on cell behavior in bone tissue engineering", Iranian Polymer Journal, 2022 Apr vol. 31, no. 8, pp.919-930, 2022.

15

Mohadeseh Hadizadeh, Mitra Naeimi, Mohammad Rafieinia, A. Karkhaneh, "A bifunctional electrospun nanocomposite wound dressing containing surfactin and curcumin: In vitro and in vivo studies", Materials Science & Engineering C, 2021 Aug vol. 129, no. 1, pp.1-11, 2021.

16

M. Shabani Samghabadi, A. Karkhaneh, A. Katbab, "Synthesis and characterization of electroconductive hydrogels based on oxidized alginate and polypyrrole-grafted gelatin as tissue scaffolds", Soft Matter, 2021 Aug vol. 17, no. 37, pp.8465-8473, 2021.

17

R. Karimi Soflou, E. Mohseni Vadeghani, A. Karkhaneh, "Controlled release of resveratrol from a composite nanofibrous scaffold: Effect of resveratrol on antioxidant activity and osteogenic differentiation", Journal of Biomedical Materials Research Part A, 2021 Jul vol. 0, no. 0, pp.1-10, 2021.

18

R. Karimi Soflou, A. Karkhaneh, "A hydrogel/particle composite with a gradient of oxygen releasing microparticle for concurrent osteogenic and chondrogenic differentiation in a single scaffold", Colloids and Surfaces B-Biointerfaces, 2021 Jul vol. 207, no. 1, pp.1-12, 2021.

19

M.S. Moraveji, H. Keshvari, A. Karkhaneh, Shahin Bonakdar, Amin Hadi, Nooshin Haghighipour, "The effect of collagen/polycaprolactone fibrous scaffold decorated with graphene nanoplatelet and low-frequency electromagnetic field on neuronal gene expression by stem cells", Advances In Nano Research, 2021 Jun vol. 10, no. 6, pp.549-557, 2021.

20

S.A. Seyyed Nasrollah, R. Karimi Soflou, A. Karkhaneh, "PEG-coated magnesium peroxide nanosheets with tunable microstructure: Effect of microstructure on concurrent oxygen and magnesium ion release", Materials Letters, 2021 Feb vol. 291, no. 1, pp.1-5, 2021.

21

F. Imani, R. Karimi Soflou, I. Shabani, A. Karkhaneh, "PLA electrospun nanofibers modified with polypyrrole-grafted gelatin as bioactive electroconductive scaffold", Polymer, 2021 Jan vol. 218, no. 123478, pp.1-11, 2021.

22

R. Karimi Soflou, S. Nejati, A. Karkhaneh, "Electroactive and antioxidant injectable in-situ forming hydrogels with tunable properties by polyethylenimine and polyaniline for nerve tissue engineering", Colloids and Surfaces B-Biointerfaces, 2021 Jan vol. 199, no. 1, pp.1-11, 2021.

23

E. Mohseni Vadeghani, R. Karimi Soflou, A. Karkhaneh, "Tunable hollow microspheres with a loading capacity of calcium phosphate nanoparticles as cell carriers: Effect of temperature and preparation conditions on microstructure", Materials Letters, 2020 Nov vol. 284, no. 1, pp.1-4, 2020.

24

S. Nejati, R. Karimi Soflou, A. Karkhaneh, "Influence of process parameters on the characteristics of oxygen-releasing poly (lactic acid) microparticles A multioptimization strategy", Polymers For Advanced Technologies, 2020 Oct vol. 0, no. 0, pp.1-13, 2020.

25

M. Saadipour, A. Karkhaneh, M. Haghbin Nazarpak, "An investigation into curcumin release from PLA particles loaded in PCL-GELATIN fibers for skin application", International Journal of Polymeric Materials and Polymeric Biomaterials, 2020 Oct vol. 0, no. 0, pp.1-10, 2020.

26

A. Mahjoubnia, M. Haghbin Nazarpak, A. Karkhaneh, "Polypyrrole-chitosan hydrogel reinforced with collagen-grafted PLA sub-micron fibers as an electrically responsive scaffold", International Journal of Polymeric Materials and Polymeric Biomaterials, 2020 Sep vol. 0, no. 0, pp.1-10, 2020.

27

S. Nejati, R. Karimi Soflou, S. Khorshidi Esfandabadi, A. Karkhaneh, "Development of an oxygen-releasing electroconductive in-situ crosslinkable hydrogel based on oxidized pectin and grafted gelatin for tissue engineering applications", Colloids and Surfaces B-Biointerfaces, 2020 Sep vol. 196, no. 1, pp.1-12, 2020.

28

E. Mohseni Vadeghani, R. Karimi Soflou, S. Khorshidi Esfandabadi, A. Karkhaneh, "Fabrication of oxygen and calcium releasing microcarriers with different internal structures for bone tissue engineering: Solid filled versus hollow microparticles", Colloids and Surfaces B-Biointerfaces, 2020 Sep vol. 197, no. 1, pp.1-11, 2020.

29

S. Khorshidi Esfandabadi, A. Karkhaneh, "A hydrogel/particle composite with gradient in oxygen releasing microparticle for oxygenation of the cartilage-to-bone interface: Modeling and experimental viewpoints", Materials Science and Engineering C-Materials For Biological Applications, 2020 Sep vol. 118, no. 1, pp.1-12, 2020.

30

Z. Naghizadeh, A. Karkhaneh, Hanieh Nokhbatolfoghahaei, Saeed Farzad?mohajeri, Maryam Rezai?rad, Mohammad M. Dehghan, Pouyan Aminishakib, Arash Khojasteh, "Cartilage regeneration with dual-drug-releasing injectable hydrogel/microparticle system: In vitro and in vivo study", Journal of Cellular Physiology, 2020 Aug vol. 0, no. 0, pp.1-11, 2020.

31

S. Yasami, A. Karkhaneh, Mohammad Ali Shokrgozar, Amir Amanzadeh, Majid Golkar, "Size effect of human epidermal growth factor-conjugated polystyrene particles on cell proliferation", Biomaterials Science, 2020 Aug vol. 8, no. 1, pp.4832-4840, 2020.

32

S. Naghavi Alhosseini, F. Moztarzadeh, A. Karkhaneh, "Genipin-cross-linked poly(vinyl alcohol) for neural scaffold", Bioinspired Biomimetic and Nanobiomaterials, 2017 Mar vol. 0, no. 0, pp.1-8, 2017.

33

S. Khorshidi, A. Solouk Mofrad, A. Karkhaneh, H. Mirzadeh, Shahriar Sharifi, S. Mazinani, "Effect of crosslinking procedure on structural, thermal, and functional performances of cellulosic nanofibers: A comparison between chemical and photochemical crosslinking", Journal of Applied Polymer Science, 2016 May vol. 0, no. 0, pp.1-9, 2016.

34

E. Dashtimoghadam, R. Nasseri Pourtakalo, A. Karkhaneh, F.S. Majedi, Nassir Mokarram, Philippe Renaud, Karl I. Jacob, "Cellulose nanowhiskers to regulate the microstructure of perfluorosulfonate ionomers for high-performance fuel cells", Journal of Materials Chemistry A, 2014 Apr vol. 2, no. 29, pp.11334-11340, 2014.

35

A. Karkhaneh, Ziba Naghizadeh, Mohammad Ali Shokrgozar, Shahin Bonakdar, A. Solouk Mofrad, Nooshin Haghighipour, "Effects of hydrostatic pressure on biosynthetic activity during chondrogenic differentiation of MSCs in hybrid scaffolds", International Journal of Artificial Organs, 2014 Mar vol. 37, no. 2, pp.142-148, 2014.

Taught Courses

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Course title

Description

Headlines

Date

1

Engineering Materials (I): Structure & Properties

Study of the Structure and Properties of Materials Used in Engineering Applications

4051

2

Protein Engineering

Introduction to Protein Engineering Methods and Their Applications in Tissue Engineering-Based Therapeutics

4051

3

Engineering Materials (I): Structure & Properties

مطالعه ساختار و خواص مواد بکار رفته در کاربردهای مهندسی

4042

4

Fundamentals of Biocompatibility & Biological Tests

آشنا یی دانشجویان با مفاهیم اساسی زیست سازگاری، برهمکنش بیومتریالهای مختلف (بیومتریال های فلزی سرامیکی، پلمری و کاامپوزیتی) با محیط بیول

4042

5

Protein Engineering

4041

6

Engineering Materials (I): Structure & Properties

4041

7

Engineering Materials (I): Structure & Properties

4032

8

Fundamentals of Biocompatibility & Biological Tests

4032

Inventions/Patents

#

Invention title

Reg. number

Country

contributers

Reg. date

Exp. date

1

Fabrication of chitosan polypyrol scaffold containing PLA fibers for nerve tissue engineering applications

2021/02/1

2038/01/19