Course Description:
It is an applied course in biomedical engineering that introduces a variety of cellular behavior including adhesion, cell migration, growth, proliferation, differentiation and morphology. The students also study the effect of different types of cellular signaling (chemical, mechanical, electromagnetic, biological signaling) on cellular behaviors; which is means to amplify its desired behavior in the cell by using a special signal.
Course Goals and Objectives:
Investigation of cellular behaviors including adhesion, cell migration, growth, proliferation, differentiation and so on. Also the effect of different types of cellular signaling on these behaviors for application in various fields in biomedical engineering
Course Topics:
1. Introduction to General Cellular Characteristics and Behaviors:
Biophysical-Biochemical properties, electromagnetic properties, biomechanical and bioelectrical properties, cell metabolism
2. Cellular Migration:
Characteristics of migrating cells, types and characteristics of migrating cells, types of migratory stimulus signals in cells, effect of cytoskeleton on cell migration, effect of cell migration on cellular behaviors, role of cell migration in biomaterial and tissue engineering, control methods cell migration and its engineering.
3. Cell Adhesion
Cell characteristics with adhesion behavior, role of receptors in cell adhesion, interaction of cell adhesion on other cellular behaviors, effect of cell adhesion in biomaterial and tissue engineering, methods of cell adhesion control engineering.
4. Cell Differentiation
Cell differentiation behavior from embryonic period to puberty, factors affecting cell differentiation, various methods of cell reprogramming.
5. Cell Growth
Cell cycle and growth rate of different cells, how to control cell growth engineering, effect of cell growth on cancer, effect of cell growth on different cell behaviors, role of membrane, cytoskeleton on cell growth.
6. Cellular Morphology
Types of cellular morphologies and interactions with the behavior of biomaterials, the effect of different morphologies on other cellular behaviors.
7. Cell Proliferation
Factors affecting cell proliferation, the role of cell proliferation in the success of tissue engineering, the interaction between biomaterials and cells in the field of proliferation, the effect of proliferation on other cellular behaviors.
8. Cellular Signaling
The effect of different types of cellular signaling (chemical, mechanical, electromagnetic, biological signaling) on cellular behaviors and vice versa on biomaterial behaviors.
9. Cellular Interactions
The course aims to:
Upon successful completion of this course, students will be able to meet these objectives:
- Be familiar with the general characteristics of the cell.
- Describe a variety of cellular behaviors including adhesion, cell migration, growth, proliferation, and differentiation.
- Describe the effect of different types of cellular signaling (chemical, mechanical, electromagnetic, biological signaling) on cellular behaviors.
Reading Resources:
1. Introductory biomechanics from cells to organisms, C. Ross Ethier and Craig A. Simmons, 2002.
2. Principles of cell engineering, Michael R. King, 2002.
3. Bioelectricity, Robert Plonsey, 2002.
4. Cell polarity, E. Bittar, 2002.
5. Cell metabolism, Cell behavior controls, B. Fleming, 2002.
6. Structure and function in cell signaling, John Nelson, 2002.
7. Signaling networks in cell shape and motility, Alberts, 2005.
8. Environmental stress and cellular response, Korsloot, 2002.
9. Cell proliferation and apoptosis, D. Hughes, 2005.
10. Principles of cell proliferation, John Health, 2010.
11. Results and problems in cell differentiation, Eckart D. Gundelfinger, 2002.
12. Cell- cell interactions, John Wolker, 2011.
13. Cell migration: signaling and mechanisms, Samuel H. H. Chan, 2010.
14. Cell cycle and growth control, Gary S. Stein, 2004.
15. The roles of membranes in cell growth and differentiation, M. B. Blaustein, 2011
16. Influence of stress on cell growth, T. Scheper, 2002.
17. Biochemistry reaction of living cells, Metzler, 2005.
18. Biomaterials as Stem cell niche, K. Roy, 2010.
Evaluation (100 total score):
Class attendance and class activity
Project
Midterm exam
Final exam